how blonde do you want it...
I suppose the main difference is that strangelets (if they exist) have an internal structure; they are composed of quarks. Black holes have no internal structure worth talking about, hence the term 'singularity'. Strangelets would also be far less dense than a black hole of the same size (where size refers to the Schwarzchild radius of the black hole). The only similarity is that they are both dense enough to show tidal effects nearby due to their gravity.
Good enough?
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